ea0021s8.2 | Role of the circadian clock in endocrinology | SFEBES2009
Gimble Jeffrey
, Wu Xiying
, Yu Gang
, Floyd Elizabeth
There is a growing body of literature indicating that circadian mechanisms regulate metabolism in adipose tissues. Genes encoding the core circadian regulatory proteins (CCRP) display a robust oscillatory expression profile in murine adipose tissue depots, as well as the bone, liver, and heart. Temporally restricted food access as well as photic stimuli can entrain the CCRP expression. In murine models, deletion or mutation of the CCRP genes, clock and PPAR gamma coa...